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Clinkenbeard, Kenneth D

Professor
Coordinator Veterinary Biomedical Sciences Graduate Program

Specialty: Veterinary microbiology





PhD, biological chemistry, The Johns Hopkins University School of Medicine, 1975
Postdoctoral fellow, University of California at Davis, School of Medicine, 1974-76
DVM, University of California at Davis, 1978

Department: Veterinary Pathobiology

Contact Information:
Veterinary Pathobiology
162 McElroy Hall
Stillwater, OK 74078
Office: (405) 744-4467
Fax: (405) 744-4461
Send eMail

Biography:

Dr. Kenneth D. Clinkenbeard is professor of veterinary pathobiology and coordinator of the Veterinary Biomedical Sciences Graduate Program at the College of Veterinary Medicine, Oklahoma State University where he teaches graduate and veterinary students and conducts research in the areas of infectious disease pathogenesis and ecology. Ken earned his PhD degree at The Johns Hopkins University School of Medicine in physiological chemistry in Albert Lehningerís department studying enzymology and was a NIH postdoctoral fellow under Nobel laureate in medicine Dr. Edwin G. Krebs at the University of California at Davis studying phosphorulation of glycogen synthase. While at UCD, he also earned his DVM degree. Dr. Clinkenbeard practiced veterinary medicine for eight years in a mixed animal practice in Redding, CA prior to coming to Olklahoma State University. He has over thirty-five years experience working with infectious diseases including disseminate histoplasmosis in dogs and cats; shipping fever, pinkeye, and E coli O157:H7 in cattle; tularemia and plague in wildlife; and chronic wasting disease in cervids. 



Fields of Interest:

Microbial pathogenesis; comparative microbial genomics; ecology of infectious diseases


Selected Publications:
  • Clinkenbeard KD, Reed WD, Mooney RA, Lane MD. Intracellular localization of the 3-hydroxy-3-methylglutaryl CoA cycle enzymes in liver: Separate cytoplasmic and mitochondrial 3-hydroxy-3-methylglutaryl CoA generating systems for cholesterogenesis and ketogenesis. J Biol Chem 1975;250:3108-3116.
  • Clinkenbeard KD, Cowell RL, Tyler RD. Disseminated histoplasmosis in cats; 12 cases (1981-1986). J Am Vet Med Assoc 1987;190:1445-1448.
  • Clinkenbeard KD, Mosier DA, Confer AW. Transmembrane pore size and role of cell swelling in cytotoxicity caused by Pasteurella haemolytica leukotoxin. Infect Immun 1989;57:420-425.
  • Li J, Clinkenbeard KD, Ritchey JW. Bovine CD18 identified as a receptor for the RTX toxin Pasteurella haemolytica leukotoxin. Vet Microbiol 1999;67:93-99.
  • Snider TA, Fabich AJ, Washburn KE, Sims WP, Blair JL, Cohen PS, Conway T, Clinkenbeard KD. Evaluation of a model for Escherichia coli O157:H7 colonization in streptomycin-treated adult cattle. Amer J Vet Res 2006;67:1914-20.
  • Petrosino JF, Xiang Q, Karpathy SE, Jiang H, Yerrapragada S, Liu Y, Gioia J, Hemphill L, Gonsales, A, Raghavan TM, Usman A, Fox GE, Highlander S, Reichard M, Morton RJ, Clinkenbeard KD,Weinstock GM. Chromosome rearrangement and diversification of Francisella tularensis revealed by the type B (OSU18) genome sequence. J Bacteriol. 2006;188:6977-85.
  • Ponnusamy D, Hartson SD, Clinkenbeard KD, Intracellular Yersinia pestis Expresses General Stress Response and Tellurite Resistance Proteins in Mouse Macrophages. Vet Microbiol 150:146-51;2011.

Courses Taught:
  • VBSC 5013 Cell and Molecular Biology
  • VBSC 5023 Pathophysiology
  • VBSC 5554 Bacterial Pathogenesis
  • VBSC 6110 Seminar
  • VMED 7610 Ecology of Infectious Diseases